New Inprocess Raman Spectrometer for Rack Mounting
The Process Guardian is a next-generation process Raman spectrometer. Equipped with Tornado Spectral Systems' revolutionary High Throughput Virtual Slit technology (HTVS™), it enables 10 – 40 times the signal yield for more accurate and faster chemical analysis. Previously difficult or impossible PAT applications are feasible with this instrument, such as biopharma USP and DSP or split-second analysis down to the ppm range. Due to the high signal yield, measurements with acceptable measuring times are possible even in ATEX operation (up to zone 0). The spectrometer is explicitly designed for in-process use: It fits into typical 19" racks and has ModBus or OPC connectivity.
- Explicit PAT Raman for process control.
- Proven High Throughput Virtual Slit technology ensures.
- Exceptional signal-to-noise ratio and fastest measurements.
- Compatible with many popular immersion and contact probes.
- Flow cells for biopharma DSP applications.
- Maintenance-free system with long-life 785 nm Raman laser.
- ModBus and OPC connectivity for easy implementation into customer process control system.
- Integrated prediction modules for SIMCA, Panorama and Peaxact.
- Documents for GMP compliant validation.
- Also available as ATEX version for safe use in EX zone 0.
- Optional four- or eight-fold multiplex variant for cost savings when equipping several production lines.
Typical areas of application for the Process Guardian
The Process Guardian enables a variety of different real-time reaction monitoring, e.g.:
- Classical chemical reaction monitoring
- Biopharma USP and DSP
- Solvent analysis
- ppm analysis
How does the Process Guardian work?
The Process Guardian is a Raman spectrometer. The substance to be examined is irradiated with a laser and the generated signal ("Raman photons") is analyzed at the detector. The Raman scattering depends on the type and structure of the analytes. Thus, molecule-specific measurements can be performed. Raman spectroscopy depends on a very good signal yield, because only one in about 1 million scattered laser photons is a usable Raman photon (more details about Raman spectroscopy here). The photon yield of conventional Raman spectrometers suffers from the fact that the incoming signals are classically truncated at an input slit, because the detectors cannot process round signals from the light guide. Losses of up to 95% are not uncommon! In contrast, the High Throughput Virtual Slit technology processes photons much more efficiently: Instead of discarding the photons that are cut away, they are superimposed on each other via a fixed mirror system in the spectrometer in such a way that almost 95% of all incoming photons arrive at the detector. Process spectrometers with HTVS™ are therefore significantly faster and deliver an unprecedented signal-to-noise ratio.
What makes the Process Guardian so unique?
Unprecedented signal yield results in tremendous speed and sensitivity. Consistent process-oriented design with direct 19" rack mounting and on-site operability without separate computer via integrated rugged display. Customized measuring probes, four- and eightfold multiplex as well as an optional ATEX rating for zone 0 - here a process Raman has been developed, which is strictly oriented to the requirements of the chemical and pharmaceutical industry.
Feasibility studies & chemometric support
Process analysical technologies benefit those who use a first-class spectrometer and create reliable chemometric models.
We provide support in evaluating the feasibility of analytical issues, e.g. with trial measurements in our laboratory or at the customer's site.
In this way, customers receive a complete package to get off to a successful start in PAT.
|Principle of operation||High-Throughput Virtual Slit (HTVS™) analysis with Raman spectroscopy|
|Size||195 mm x 446 mm x 626 mm (suitable for 19" rack mounting)|
|Laser power||5 mW bis 495 mW|
|Spectral range||200 cm-1 till 3300 cm-1 (Raman shift from 785 nm excitation)|
|Probes||Immersion & Non-Contact, Flow Cells
|Fiber optic cable length||Various types and lengths available|
|Pharma-ready:||21 CFR Part 11 and IQ / OQ protocols|
|Data management||OPC, ModBus|
|Data Transfer||USB, Ethernet (RJ45)|
|Ext. power supply||100 – 240 V AC, 60 W maximum|
Various, individually modifiable measuring probes, e.g. immersion probes from Marqmetrix, contactless probes from Hellma or Hudson probe especially for measuring powders.
>> more information on measuring probes
OPIS35 ATEX module
Hardware module for intrinsically safe operation in EX areas up to zone 0.
>> more information
Hardware module for simultaneous operation of four of the eight channels with a Process Guardian.
>> more information
Hg-Ar lamp and white light source for X- and Y-axis calibration.
Fibre optic maintenance kit
Fiber optic microscope, cleaning kits for fiber optic ends and input ports.
USB-connected powermeter for determination of laser power.
Fiber optic cable
Fiber optic cable in various designs and lengths.
For measuring liquids in a flow-through setting, e.g. downstream biopharma.
For measurement of samples in test cuvettes.
Do you have questions?
Are you interested in the Process Guardian?
Our team of experts is here to advise you and discuss your needs.